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Literature summary extracted from

  • Yogalingam, G.; Litjens, T.; Bielicki, J.; Crawley, A.C.; Muller, V.; Anson, D.S.; Hopwood, J.J.
    Feline mucopolysaccharidosis type VI. Characterization of recombinant N-acetylgalactosamine 4-sulfatase and identification of a mutation causing the disease (1996), J. Biol. Chem., 271, 27259-27265.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.6.12 medicine enzyme replacement in MPS IV feline fibroblast Felis catus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.6.12
-
 Felis catus

Protein Variants

EC Number Protein Variants Comment Organism
3.1.6.12 L476P mutation in MPS IV cats Felis catus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O Felis catus acts also on N-acetylglucosamine 4-sulfate N-acetyl-D-galactosamine units + sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.12 Felis catus
-
 siamese cat, feline model of human Maroteaux-Lamy Syndrom
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.12 heart
-
 Felis catus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.12 4-methylumbelliferyl sulfate + H2O
-
 Felis catus 4-methylumbelliferone + sulfate
-
 ?
3.1.6.12 N-acetygalactosamine 4-sulfate-(1-4)-beta-glucuronic acid-(1-3)-beta-N-acetylgalactosaminitol 4-sulfate + H2O
-
 Felis catus N-acetygalactosamine-(1-4)-beta glucuronic acid-(1-3)-beta N-acetylgalactosaminitol 4-sulfate + sulfate
-
 ?
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O acts also on N-acetylglucosamine 4-sulfate Felis catus N-acetyl-D-galactosamine units + sulfate
-
 ?