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Literature summary extracted from

  • Nicholls, R.G.; Roy, A.B.
    Arylsulfatases (1971), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 5, 21-41.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.6.12 acetate
-
 Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.8 Ag+
-
 Bos taurus
3.1.6.8 Cu2+
-
 Bos taurus
3.1.6.8 hydrazine
-
 Bos taurus
3.1.6.8 hydroxylamine
-
 Bos taurus
3.1.6.8 K2SO4
-
 Bos taurus
3.1.6.8 p-hydroxymercuribenzoate
-
 Bos taurus
3.1.6.8 SO42-
-
 Bos taurus
3.1.6.12 SO42-
-
 Bos taurus
3.1.6.12 SO42-
-
 Macropus sp.

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.6.8 0.47
-
 2-hydroxy-5-nitrophenyl sulfate
-
 Bos taurus
3.1.6.8 0.76
-
 pyridyl 4-sulfate
-
 Bos taurus
3.1.6.8 4.4
-
 2-nitropyridyl 3-sulfate
-
 Bos taurus
3.1.6.8 6.5
-
 2-nitrophenyl sulfate
-
 Bos taurus
3.1.6.8 9.5
-
 phenanthryl sulfate
-
 Bos taurus
3.1.6.8 31
-
 pyridyl 3-sulfate
-
 Bos taurus
3.1.6.8 38
-
 2-hydroxyphenyl sulfate
-
 Bos taurus
3.1.6.8 53
-
 4-nitrophenyl sulfate
-
 Bos taurus
3.1.6.8 53
-
 Naphthyl sulfate
-
 Bos taurus
3.1.6.8 63
-
 5,6,7,8-tetrahydro-2-naphthyl sulfate
-
 Bos taurus
3.1.6.8 77
-
 3-nitrophenyl sulfate
-
 Bos taurus
3.1.6.8 310
-
 phenyl sulfate
-
 Bos taurus
3.1.6.12 1.86
-
 nitrocatechol 4-sulfate
-
 Bos taurus
3.1.6.12 10.8
-
 p-Nitrophenyl sulfate
-
 Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.6.12 Cl- activation Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.6.12 45000
-
 gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.8 cerebroside 3-sulfate + H2O Bos taurus
-
 cerebroside + sulfate
-
 ?
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O Homo sapiens acts also on N-acetylglucosamine 4-sulfate N-acetyl-D-galactosamine units + sulfate
-
 ?
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O Bos taurus acts also on N-acetylglucosamine 4-sulfate N-acetyl-D-galactosamine units + sulfate
-
 ?
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O Macropus sp. acts also on N-acetylglucosamine 4-sulfate N-acetyl-D-galactosamine units + sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.8 Bos taurus
-
-
-
3.1.6.12 Bos taurus
-
-
-
3.1.6.12 Homo sapiens
-
-
-
3.1.6.12 Macropus sp.
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.6.8 glycoprotein
-
 Bos taurus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.1.6.8 a cerebroside 3-sulfate + H2O = a cerebroside + sulfate hydrolyses galactose-3-sulfate residues in a number of lipids, also hydrolyses ascorbate 2-sulfate and many phenol sulfates, enzymes catalyze in addition to reaction of EC 3.1.6.8 also arylsulfatase reaction EC 3.1.6.1 Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.12 brain
-
 Homo sapiens
-
3.1.6.12 liver
-
 Homo sapiens
-
3.1.6.12 liver
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.8 2-hydroxy-5-nitrophenyl sulfate + H2O
-
 Bos taurus 2-hydroxy-5-nitrophenol + sulfate
-
 ?
3.1.6.8 2-hydroxyphenyl sulfate + H2O
-
 Bos taurus 2-hydroxyphenol + sulfate
-
 ?
3.1.6.8 2-naphthyl sulfate + H2O
-
 Bos taurus 2-naphthol + sulfate
-
 ?
3.1.6.8 2-nitrophenyl sulfate + H2O
-
 Bos taurus 2-nitrophenol + sulfate
-
 ?
3.1.6.8 2-nitropyridyl 3-sulfate + H2O
-
 Bos taurus 2-nitropyridin-3-ol + sulfate
-
 ?
3.1.6.8 3-nitrophenyl sulfate + H2O
-
 Bos taurus 3-nitrophenol + sulfate
-
 ?
3.1.6.8 4-nitrophenyl sulfate + H2O
-
 Bos taurus 4-nitrophenol + sulfate
-
 ?
3.1.6.8 5,6,7,8-tetrahydro-2-naphthyl sulfate + H2O
-
 Bos taurus 5,6,7,8-tetrahydro-2-naphthol + sulfate
-
 ?
3.1.6.8 cerebroside 3-sulfate + H2O
-
 Bos taurus cerebroside + sulfate
-
 ?
3.1.6.8 naphthyl sulfate + H2O
-
 Bos taurus naphthol + sulfate
-
 ?
3.1.6.8 nitrocatechol sulfate + H2O
-
 Bos taurus nitrocatechol + sulfate
-
 ?
3.1.6.8 phenanthryl sulfate + H2O
-
 Bos taurus phenanthrol + sulfate
-
 ?
3.1.6.8 phenyl sulfate + H2O
-
 Bos taurus phenol + sulfate
-
 ?
3.1.6.8 pyridyl 3-sulfate + H2O
-
 Bos taurus pyridol + sulfate
-
 ?
3.1.6.8 pyridyl 4-sulfate + H2O
-
 Bos taurus pyridol + sulfate
-
 ?
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O acts also on N-acetylglucosamine 4-sulfate Homo sapiens N-acetyl-D-galactosamine units + sulfate
-
 ?
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O acts also on N-acetylglucosamine 4-sulfate Bos taurus N-acetyl-D-galactosamine units + sulfate
-
 ?
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O acts also on N-acetylglucosamine 4-sulfate Macropus sp. N-acetyl-D-galactosamine units + sulfate
-
 ?
3.1.6.12 p-nitrocatechol sulfate + H2O
-
 Bos taurus p-nitrocatechol + sulfate
-
 ?
3.1.6.12 p-nitrocatechol sulfate + H2O enzymes catalyze in addition to reaction of EC 3.1.6.12 also arylsulfatase reaction , see also EC 3.1.6.1 Homo sapiens p-nitrocatechol + sulfate
-
 ?
3.1.6.12 p-nitrophenyl sulfate + H2O
-
 Bos taurus p-nitrophenol + sulfate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.6.8 dimer between pH 5.5-6.5, depends also on ionic strength Bos taurus
3.1.6.8 monomer at pH 5.6 monomer, at pH 4.8 tetramer Bos taurus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.6.8 65
-
 5 min, no loss of activity Bos taurus