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Literature summary extracted from

  • McGovern, M.M.; Vine, D.T.; Haskins, M.E.; Desnick, R.J.
    Purification and properties of feline and human arylsulfatase B isozymes. Evidence for feline homodimeric and human monomeric structures (1982), J. Biol. Chem., 257, 12605-12610.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.6.12 EDTA
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.6.12 K2HPO4
-
 Felis catus
3.1.6.12 K2HPO4
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.6.12 1.2
-
 nitrocatechol sulfate
-
 Homo sapiens
3.1.6.12 1.2
-
 nitrocatechol sulfate
-
 Felis catus
3.1.6.12 3.6
-
 nitrocatechol sulfate
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.6.12 Mg2+ stimulates Homo sapiens
3.1.6.12 Mn2+ stimulates Homo sapiens
3.1.6.12 Mn2+ stimulates Felis catus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.6.12 38000
-
 1 * 38000, SDS-PAGE Homo sapiens
3.1.6.12 41000
-
 2 * 41000, SDS-PAGE after suberimidate treatment Felis catus
3.1.6.12 48000
-
 gel filtration Homo sapiens
3.1.6.12 100000
-
 gel filtration Felis catus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O Homo sapiens acts also on N-acetylglucosamine 4-sulfate N-acetyl-D-galactosamine units + sulfate
-
 ?
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O Felis catus acts also on N-acetylglucosamine 4-sulfate N-acetyl-D-galactosamine units + sulfate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.6.12 Felis catus
-
-
-
3.1.6.12 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.6.12
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.6.12 liver
-
 Homo sapiens
-
3.1.6.12 liver
-
 Felis catus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O acts also on N-acetylglucosamine 4-sulfate Homo sapiens N-acetyl-D-galactosamine units + sulfate
-
 ?
3.1.6.12 N-acetyl-D-galactosamine 4-sulfate units + H2O acts also on N-acetylglucosamine 4-sulfate Felis catus N-acetyl-D-galactosamine units + sulfate
-
 ?
3.1.6.12 p-nitrocatechol sulfate + H2O enzymes catalyze in addition to reaction of EC 3.1.6.12 also arylsulfatase reaction , see also EC 3.1.6.1 Homo sapiens p-nitrocatechol + sulfate
-
 ?
3.1.6.12 p-nitrocatechol sulfate + H2O enzymes catalyze in addition to reaction of EC 3.1.6.12 also arylsulfatase reaction , see also EC 3.1.6.1 Felis catus p-nitrocatechol + sulfate
-
 ?
3.1.6.12 UDP-N-acetylgalactosamine-4-sulfate + H2O
-
 Homo sapiens UDP-N-acetylgalactosamine + sulfate
-
 ?
3.1.6.12 UDP-N-acetylgalactosamine-4-sulfate + H2O
-
 Felis catus UDP-N-acetylgalactosamine + sulfate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.6.12 dimer
-
 Homo sapiens
3.1.6.12 dimer 2 * 41000, SDS-PAGE after suberimidate treatment Felis catus
3.1.6.12 monomer
-
 Felis catus
3.1.6.12 monomer 1 * 38000, SDS-PAGE Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.6.12 60
-
 t1/2: 30 min Homo sapiens
3.1.6.12 60
-
 20 min Homo sapiens
3.1.6.12 60
-
 20 min Felis catus
3.1.6.12 60
-
 t1/2: 68 min Felis catus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.6.12 5.7
-
-
 Homo sapiens
3.1.6.12 5.7
-
-
 Felis catus