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Literature summary extracted from
- Platelet aggregation and sphingomyelinase D activity of a purified toxin from the venom of Loxosceles rescula (1981), Biochim. Biophys. Acta, 678, 467-476.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.41 | additional information | enzyme induced human platelet aggregation is inhibited by EDTA over a range of 0.6 to 3.0 mM | Loxosceles reclusa |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.41 | 32000 | - |
4 * 32000, SDS-PAGE | Loxosceles reclusa |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.41 | additional information | Loxosceles reclusa | enzyme is a poisonous toxin which induces platelet aggregation | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.41 | Loxosceles reclusa | - |
brown recluse spider | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.4.41 | partial | Loxosceles reclusa |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.1.4.41 | venom gland | - |
Loxosceles reclusa | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.1.4.41 | additional information | - |
- |
Loxosceles reclusa |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.41 | L-alpha-[palmitoyl-1]lysophosphatidylcholine + H2O | - |
Loxosceles reclusa | ? | - |
? | |
| 3.1.4.41 | additional information | enzyme is a poisonous toxin which induces platelet aggregation | Loxosceles reclusa | ? | - |
? | |
| 3.1.4.41 | sphingomyelin + H2O | - |
Loxosceles reclusa | N-acylsphingosylphosphate + choline | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.1.4.41 | tetramer | 4 * 32000, SDS-PAGE | Loxosceles reclusa |
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