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Literature summary extracted from
- Molecular and biochemical properties and physiological roles of plant phospholipase D (1999), Biochim. Biophys. Acta, 1439, 151-166.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.4 | phosphatidylethanolamine | required for maximal activity of the beta and gamma-enzymes | Arabidopsis sp. |  |
| 3.1.4.4 | phosphatidylinositol 4,5-bisphosphate | - |
Rattus norvegicus | |
| 3.1.4.4 | phosphatidylinositol 4,5-bisphosphate | binding is modulated by Ca2+ | Arabidopsis sp. | |
| 3.1.4.4 | phosphatidylinositol 4,5-bisphosphate | only in vitro | Homo sapiens | |
| 3.1.4.4 | phosphatidylinositol phosphate | - |
Arabidopsis sp. | |
| 3.1.4.4 | phosphatidylinositol phosphate | only in vitro | Homo sapiens | |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.1.4.4 | - |
Saccharomyces cerevisiae |
| 3.1.4.4 | - |
Ricinus communis |
| 3.1.4.4 | - |
Brassica oleracea |
| 3.1.4.4 | - |
Spuriopimpinella brachycarpa |
| 3.1.4.4 | - |
Vigna unguiculata |
| 3.1.4.4 | - |
Nicotiana tabacum |
| 3.1.4.4 | three distinct cDNAs for the enzyme: alpha, beta, gamma | Arabidopsis sp. |
| 3.1.4.4 | two distinct cDNAs for the enzyme: type 1, type 2 | Oryza sativa |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.1.4.4 | Ca2+ | - |
Rattus norvegicus | |
| 3.1.4.4 | Ca2+ | Ca2+ dependent and independent enzymes | Saccharomyces cerevisiae | |
| 3.1.4.4 | Ca2+ | 20-100 mM required for maximal activity in plants | Zea mays | |
| 3.1.4.4 | Ca2+ | 20-100 mM required for maximal activity in plants | Arabidopsis sp. | |
| 3.1.4.4 | Ca2+ | 20-100 mM required for maximal activity in plants | Ricinus communis | |
| 3.1.4.4 | Ca2+ | 20-100 mM required for maximal activity in plants | Brassica oleracea | |
| 3.1.4.4 | Ca2+ | 20-100 mM required for maximal activity in plants | Oryza sativa | |
| 3.1.4.4 | Ca2+ | 20-100 mM required for maximal activity in plants | Spuriopimpinella brachycarpa | |
| 3.1.4.4 | Ca2+ | 20-100 mM required for maximal activity in plants | Vigna unguiculata | |
| 3.1.4.4 | Ca2+ | 20-100 mM required for maximal activity in plants | Nicotiana tabacum | |
| 3.1.4.4 | Ca2+ | micromolar levels for maximal activity | Mus musculus | |
| 3.1.4.4 | Ca2+ | micromolar levels for maximal activity | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.4 | phospholipid + H2O | Mus musculus | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | Homo sapiens | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | Rattus norvegicus | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | Saccharomyces cerevisiae | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | Zea mays | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | Arabidopsis sp. | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | Ricinus communis | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | Brassica oleracea | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | Oryza sativa | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | Catharanthus roseus | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | Spuriopimpinella brachycarpa | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | Vigna unguiculata | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | Nicotiana tabacum | phosphoric ester hydrolysis | phosphatidic acid + alcohol | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.1.4.4 | Arabidopsis sp. | - |
- |
- |
| 3.1.4.4 | Brassica oleracea | - |
- |
- |
| 3.1.4.4 | Catharanthus roseus | - |
madagascar periwinkles | - |
| 3.1.4.4 | Homo sapiens | - |
- |
- |
| 3.1.4.4 | Mus musculus | - |
- |
- |
| 3.1.4.4 | Nicotiana tabacum | P93400 | tabacco | - |
| 3.1.4.4 | Oryza sativa | - |
- |
- |
| 3.1.4.4 | Rattus norvegicus | - |
- |
- |
| 3.1.4.4 | Ricinus communis | - |
castor bean | - |
| 3.1.4.4 | Saccharomyces cerevisiae | - |
yeast | - |
| 3.1.4.4 | Spuriopimpinella brachycarpa | - |
- |
- |
| 3.1.4.4 | Vigna unguiculata | O04865 | cow pea | - |
| 3.1.4.4 | Zea mays | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.1.4.4 | complete to homogeneity | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Mus musculus | 1,2-diacylglycerophosphate + choline | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Homo sapiens | 1,2-diacylglycerophosphate + choline | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Rattus norvegicus | 1,2-diacylglycerophosphate + choline | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Saccharomyces cerevisiae | 1,2-diacylglycerophosphate + choline | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Arabidopsis sp. | 1,2-diacylglycerophosphate + choline | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Ricinus communis | 1,2-diacylglycerophosphate + choline | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Brassica oleracea | 1,2-diacylglycerophosphate + choline | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Oryza sativa | 1,2-diacylglycerophosphate + choline | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Spuriopimpinella brachycarpa | 1,2-diacylglycerophosphate + choline | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Vigna unguiculata | 1,2-diacylglycerophosphate + choline | - |
? | |
| 3.1.4.4 | phosphatidylcholine + H2O | - |
Nicotiana tabacum | 1,2-diacylglycerophosphate + choline | - |
? | |
| 3.1.4.4 | phosphatidylglycerol + H2O | - |
Arabidopsis sp. | glycerol + diacylglycerophosphate | - |
? | |
| 3.1.4.4 | phosphatidylglycerol + H2O | - |
Brassica oleracea | glycerol + diacylglycerophosphate | - |
? | |
| 3.1.4.4 | phosphatidylinositol + H2O | - |
Arabidopsis sp. | 1,2-diacylglycerophosphate + inositol | - |
? | |
| 3.1.4.4 | phosphatidylinositol + H2O | - |
Catharanthus roseus | 1,2-diacylglycerophosphate + inositol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | phosphoric ester hydrolysis | Mus musculus | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | phosphoric ester hydrolysis | Homo sapiens | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | phosphoric ester hydrolysis | Rattus norvegicus | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | phosphoric ester hydrolysis | Saccharomyces cerevisiae | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | phosphoric ester hydrolysis | Zea mays | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | phosphoric ester hydrolysis | Arabidopsis sp. | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | phosphoric ester hydrolysis | Ricinus communis | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | phosphoric ester hydrolysis | Brassica oleracea | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | phosphoric ester hydrolysis | Oryza sativa | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | phosphoric ester hydrolysis | Catharanthus roseus | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | phosphoric ester hydrolysis | Spuriopimpinella brachycarpa | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | phosphoric ester hydrolysis | Vigna unguiculata | phosphatidic acid + alcohol | - |
? | |
| 3.1.4.4 | phospholipid + H2O | phosphoric ester hydrolysis | Nicotiana tabacum | phosphatidic acid + alcohol | - |
? | |
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