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Literature summary extracted from

  • Hodgkin, M.N.; Clark, J.M.; Rose, S.; Saqib, K.; Wakelam, M.J.
    Characterization of the regulation of phospholipase D activity in the detergent-insoluble fraction of HL60 cells by protein kinase C and small G-proteins (1999), Biochem. J., 339, 87-93.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.4 ADP-ribosylation factor required for activity Homo sapiens
3.1.4.4 ADP-ribosylation factor GTP dependent activation Homo sapiens
3.1.4.4 GTP
-
 Homo sapiens
3.1.4.4 phorbol 12-myristate 13-acetate phorbol ester stimulation involves proteinkinase C but not ADP-ribosylation factor proteins Homo sapiens
3.1.4.4 Protein kinase C
-
 Homo sapiens
3.1.4.4 RhoA only in synergy with ARF1 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.4 expression in Spodoptera frugiperda Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.4 membrane detergent insoluble fraction Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.4 phospholipid + alcohol Homo sapiens transphosphaditylation phospholipid + alcohol
-
 ?
3.1.4.4 phospholipid + H2O Homo sapiens phosphoric ester hydrolysis phosphatidic acid + alcohol
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.4 HL-60 cell human leucemia cell line Homo sapiens
-
3.1.4.4 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.4 phosphatidylcholine + butanol
-
 Homo sapiens phosphatidylbutanol + choline
-
 ?
3.1.4.4 phosphatidylcholine + H2O
-
 Homo sapiens 1,2-diacylglycerophosphate + choline
-
 ?
3.1.4.4 phospholipid + alcohol transphosphaditylation Homo sapiens phospholipid + alcohol
-
 ?
3.1.4.4 phospholipid + H2O phosphoric ester hydrolysis Homo sapiens phosphatidic acid + alcohol
-
 ?