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Literature summary extracted from

  • Duan, R.D.; Nilsson, A.
    Purification of a newly identified alkaline sphingomyelinase in human bile and effects of bile salts and phosphatidylcholine on enzyme activity (1997), Hepatology, 26, 823-830.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.4.12 cholate
-
Homo sapiens
3.1.4.12 glycocholate
-
Homo sapiens
3.1.4.12 salts trihydroxy- and dihydroxy-bile salt Homo sapiens
3.1.4.12 taurocholate
-
Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 3-[(3-cholamidopropyl)dimethyl-ammonio]-1-propanesulfonate inhibits taurocholate-induced activation Homo sapiens
3.1.4.12 phosphorylcholine
-
Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.12 0.025
-
sphingomyelin
-
Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.12 95000
-
1 * 95000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.12
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 bile
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 phosphatidylcholine + H2O
-
Homo sapiens diacylglycerol + choline phosphate
-
?
3.1.4.12 sphingomyelin + H2O
-
Homo sapiens N-acylsphingosine + choline phosphate
-
?

Subunits

EC Number Subunits Comment Organism
3.1.4.12 monomer 1 * 95000, SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 9
-
-
Homo sapiens