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Literature summary extracted from

  • Vanha-Perttula, T.
    Sphingomyelinases in human, bovine and porcine seminal plasma (1988), FEBS Lett., 233, 263-267.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.12 Chelating agents
-
 Bos taurus
3.1.4.12 Cu2+
-
 Bos taurus
3.1.4.12 Cu2+
-
 Homo sapiens
3.1.4.12 Cu2+
-
 Sus scrofa
3.1.4.12 Fe2+
-
 Bos taurus
3.1.4.12 Hg2+
-
 Bos taurus
3.1.4.12 Pb2+
-
 Bos taurus
3.1.4.12 Zn2+
-
 Bos taurus
3.1.4.12 Zn2+
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.4.12 Cd2+
-
 Bos taurus
3.1.4.12 Co2+
-
 Bos taurus
3.1.4.12 Mn2+
-
 Bos taurus
3.1.4.12 Ni2+
-
 Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.12 60000
-
 x * 60000, SDS-PAGE Bos taurus
3.1.4.12 160000
-
 native PAGE Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.4.12 sphingomyelin + H2O Homo sapiens
-
 ?
-
 ?
3.1.4.12 sphingomyelin + H2O Bos taurus
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.12 Bos taurus
-
 bull
-
3.1.4.12 Homo sapiens
-
-
-
3.1.4.12 Sus scrofa
-
 boar
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.1.4.12 325fold Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.12 cauda epididymis
-
 Bos taurus
-
3.1.4.12 seminal plasma
-
 Homo sapiens
-
3.1.4.12 seminal plasma
-
 Sus scrofa
-
3.1.4.12 seminal plasma
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.4.12 additional information
-
 different assay conditions, substrates etc. Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.12 hexadecanoyl-p-nitrophenylphosphorylcholine + H2O
-
 Homo sapiens hexadecanoyl-p-nitrophenol + choline phosphate
-
 ?
3.1.4.12 hexadecanoyl-p-nitrophenylphosphorylcholine + H2O
-
 Bos taurus hexadecanoyl-p-nitrophenol + choline phosphate
-
 ?
3.1.4.12 N-methylsphingomyelin + H2O
-
 Homo sapiens ?
-
 ?
3.1.4.12 N-methylsphingomyelin + H2O
-
 Sus scrofa ?
-
 ?
3.1.4.12 N-methylsphingomyelin + H2O
-
 Bos taurus ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Homo sapiens ?
-
 ?
3.1.4.12 sphingomyelin + H2O
-
 Bos taurus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.1.4.12 ?
-
 Homo sapiens
3.1.4.12 ? x * 60000, SDS-PAGE Bos taurus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.1.4.12 55
-
 up to Bos taurus

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
3.1.4.12 50
-
 50% suppression Homo sapiens
3.1.4.12 50
-
 50% suppression Sus scrofa
3.1.4.12 55
-
 stable at Bos taurus
3.1.4.12 65
-
 15 min, 50% loss of activity Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.4.12 4 5
-
 Homo sapiens
3.1.4.12 4 5
-
 Sus scrofa
3.1.4.12 6.5
-
-
 Bos taurus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.4.12 5 8
-
 Homo sapiens
3.1.4.12 5 8
-
 Bos taurus