Literature summary extracted from

Methieux, G.; Zitoun, C.
Mechanisms by which fatty-acyl-CoA esters inhibit or activate glucose-6-phosphasaes in intact and detergent-treated rat liver microsomes (1996), Eur. J. Biochem., 235, 799-803.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.1.3.9	fatty-acyl-CoA	with chain-length equal to or higher than 16, at 0.001-0.002 mM, the inhibitory effect on the enzyme of untreated microsomes is either partially or totally cancelled, or even changes into an activation effect at higher concentrations, the inhibition is fully reversible in presence of bovine serum albumin. With medium chain-length, 10-14 carbons inhibit the enzyme of untreated microsomes in a dose-dependent manner in the range 0.001-0.02 mM, the higher the chain length, the stronger the inhibitory effect	Rattus norvegicus
3.1.3.9	myristoyl-CoA	uncompetitive inhibition of enzyme in untreated microsomes, non-competitive inhibition of enzyme from detergent-treated microsomes	Rattus norvegicus

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.1.3.9	microsome	-	Rattus norvegicus	-	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.1.3.9	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.1.3.9	liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.1.3.9	D-glucose 6-phosphate + H2O	-	Rattus norvegicus	D-glucose + phosphate	-	?

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Release 2023.1 (January 2023)