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Literature summary extracted from

  • Bowley, M.; Cooling, J.; Burditt, S.L.; Brindley, D.N.
    The effects of amphiphilic cationic drugs and inorganic cations on the activity of phosphatidate phosphohydrolase (1977), Biochem. J., 165, 447-454.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.3.4 chlorpromazine stimulates in absence of added Mg2+ Rattus norvegicus
3.1.3.4 spermidine stimulates Rattus norvegicus
3.1.3.4 spermine stimulates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.4 Ca2+ inhibition at optimal concentrations of Mg2+ Rattus norvegicus
3.1.3.4 chlorpromazine competitive inhibition at optimal concentrations of Mg2+ Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.4 Ca2+ stimulates Rattus norvegicus
3.1.3.4 Co2+ stimulates Rattus norvegicus
3.1.3.4 Fe2+ stimulates Rattus norvegicus
3.1.3.4 Fe3+ stimulates Rattus norvegicus
3.1.3.4 Mg2+ required Rattus norvegicus
3.1.3.4 Mn2+
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.4 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.4 phosphatidic acid + H2O
-
 Rattus norvegicus 1,2-diacyl-sn-glycerol + phosphate
-
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