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Literature summary extracted from

  • Feaster, S.R.; Lee, K.; Baker, N.; Hui, D.Y.; Quinn, D.M.
    Molecular recognition by cholesterol esterase of active site ligands: structure-reactivity effects for inhibition by aryl carbamates and subsequent carbamylenzyme turnover (1996), Biochemistry, 35, 16723-16734.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.13 sodium taurocholic acid modulate lack of bile salt effect on fatty acid recognition Rattus sp.
3.1.1.13 sodium taurocholic acid modulates both the steroid and fatty acid binding sites Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.13 2-naphthyl-N-butyl carbamate biphasic time course, reversible non-covalent enzyme-carbamate complex Rattus sp.
3.1.1.13 aryl-N-alkyl carbamates
-
 Rattus sp.
3.1.1.13 aryl-N-alkyl carbamates
-
 Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.1.13 cholesteryl esters + H2O Sus scrofa fatty acid binding site more hydrophobic than steroid binding site cholesterol + fatty acid
-
 r
3.1.1.13 cholesteryl esters + H2O Rattus sp. fatty acid binding site more hydrophobic than steroid binding site cholesterol + fatty acid
-
 r

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.13 Rattus sp.
-
-
-
3.1.1.13 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.13 pancreas
-
 Sus scrofa
-
3.1.1.13 pancreas
-
 Rattus sp.
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.13 cholesteryl esters + H2O fatty acid binding site more hydrophobic than steroid binding site Sus scrofa cholesterol + fatty acid
-
 r
3.1.1.13 cholesteryl esters + H2O fatty acid binding site more hydrophobic than steroid binding site Rattus sp. cholesterol + fatty acid
-
 r
3.1.1.13 p-nitrophenyl butyrate + H2O
-
 Sus scrofa p-nitrophenol + butanoic acid
-
 ?
3.1.1.13 p-nitrophenyl butyrate + H2O
-
 Rattus sp. p-nitrophenol + butanoic acid
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.13 CEase
-
 Sus scrofa
3.1.1.13 CEase
-
 Rattus sp.