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Literature summary extracted from

  • Jolivet, J.
    Human 5,10-methenyltetrahydrofolate synthetase (1997), Methods Enzymol., 281, 162-170.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
6.3.3.2 cytsolic enzyme Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.3.2 5-Formyltetrahydrohomofolate most potent inhibitor Homo sapiens
6.3.3.2 5-methyltetrahydrofolate competitive with respect to 5-formyltetrahydrofolate Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.3.2 0.0006
-
 (6S)-5-formyltetrahydropteroyl-pentaglutamate cytosolic enzyme Homo sapiens
6.3.3.2 0.0008
-
 (6S)-5-formyltetrahydropteroyl pentaglutamate mitochondrial enzyme Homo sapiens
6.3.3.2 0.002
-
 (6S)-5-formyltetrahydrofolate
-
 Homo sapiens
6.3.3.2 0.0044
-
 (6R,S)-5-formyltetrahydropteroyl-Glu cytosolic enzyme Homo sapiens
6.3.3.2 0.0047
-
 (6R,S)-5-formyltetrahydropteroyl-Glu mitochondrial enzyme Homo sapiens
6.3.3.2 0.02
-
 ATP cytosolic enzyme Homo sapiens
6.3.3.2 0.022
-
 ATP mitochondrial enzyme Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
6.3.3.2 cytosol
-
 Homo sapiens 5829
-
6.3.3.2 mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.3.3.2 25000
-
-
 Homo sapiens
6.3.3.2 27000
-
 PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
6.3.3.2 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.3.3.2
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.3.3.2 liver
-
 Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
6.3.3.2 -80°C, pH 7.0, 0.1% v/v Tween 20, 10% v/v glycerol, stable for several months Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.3.2 ATP + (6R,S)-5-formyltetrahydropteroyl-Glu
-
 Homo sapiens ?
-
 ?
6.3.3.2 ATP + (6S)-5-formyltetrahydropteroyl-pentaglutamate
-
 Homo sapiens ?
-
 ?
6.3.3.2 ATP + 5-formyltetrahydrofolate
-
 Homo sapiens ADP + phosphate + 5,10-methylenetetrahydrofolate
-
 ?
6.3.3.2 ATP + 5-formyltetrahydropteroyl-pentaglutamate
-
 Homo sapiens ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
6.3.3.2 6.5
-
 cytosolic enzyme Homo sapiens