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Literature summary extracted from

  • Vellekamp, G.J.; Kull, F.J.
    Allotropism in aspartyl-tRNA synthetase from porcine thyroid (1981), Eur. J. Biochem., 118, 261-269.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.12 K2HPO4 inhibits enzyme forms PC-1 and PC-2, PC-3 is stimulated (optimal concentration 75 mM) Sus scrofa
6.1.1.12 KCl inhibits enzyme forms PC-1 and PC-2, PC-3 is stimulated (optimal concentration 75 mM) Sus scrofa
6.1.1.12 NaCl inhibits enzyme forms PC-1 and PC-2 much more than PC-3 Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
6.1.1.12 K2HPO4 enzyme form PC-3 is stimulated, optimal concentration 75 mM, enzyme form PC-1 and enzyme form PC-2 are inhibited Sus scrofa
6.1.1.12 KCl enzyme form PC-3 is stimulated, optimal concentration 75 mM, enzyme form PC-1 and enzyme form PC-2 are inhibited Sus scrofa
6.1.1.12 PO43- appears to act synergistically with K+ in stimulation of enzyme form PC-3, no effect on either enzyme form PC-1 or enzyme form PC-2 Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
6.1.1.12 150000
-
 gel filtration, PC-1 and PC-2 Sus scrofa
6.1.1.12 500000
-
 gel filtration, PC-3, possibly PC-3 represents a large complex of aminoacyl-tRNA synthetases Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.12 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
6.1.1.12 2 enzyme forms: PC-1, PC-2 and PC-3 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
6.1.1.12 thyroid gland
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.1.1.12 ATP + L-aspartate + tRNAAsp
-
 Sus scrofa AMP + diphosphate + L-aspartyl-tRNAAsp
-
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