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Literature summary extracted from

  • Griffin, M.J.; Brown, G.M.
    The biosynthesis of folic acid. III. Enzymatic formation of dihydrofolic acid from dihydropteroic acid and of tetrahydropteroylpolyglutamic acid compounds from tetrahydrofolic acid (1964), J. Biol. Chem., 239, 310-316.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.12 Corynebacterium sp.
-
 enzyme posseses both dihydrofolate synthetase activity and folylpolyglutamate synthetase activity
-
6.3.2.12 Enterococcus faecalis
-
-
-
6.3.2.12 Escherichia coli
-
-
-
6.3.2.12 Mycobacterium avium
-
-
-
6.3.2.12 Mycolicibacterium phlei
-
-
-
6.3.2.12 Neurospora crassa
-
-
-
6.3.2.12 Priestia megaterium
-
-
-
6.3.2.12 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.12 ATP + 7,8-dihydropteroate + L-Glu
-
 Escherichia coli ADP + phosphate + 7,8-dihydrofolate
-
 ?
6.3.2.12 ATP + 7,8-dihydropteroate + L-Glu
-
 Saccharomyces cerevisiae ADP + phosphate + 7,8-dihydrofolate
-
 ?
6.3.2.12 ATP + 7,8-dihydropteroate + L-Glu
-
 Neurospora crassa ADP + phosphate + 7,8-dihydrofolate
-
 ?
6.3.2.12 ATP + 7,8-dihydropteroate + L-Glu
-
 Priestia megaterium ADP + phosphate + 7,8-dihydrofolate
-
 ?
6.3.2.12 ATP + 7,8-dihydropteroate + L-Glu
-
 Enterococcus faecalis ADP + phosphate + 7,8-dihydrofolate
-
 ?
6.3.2.12 ATP + 7,8-dihydropteroate + L-Glu
-
 Corynebacterium sp. ADP + phosphate + 7,8-dihydrofolate
-
 ?
6.3.2.12 ATP + 7,8-dihydropteroate + L-Glu
-
 Mycolicibacterium phlei ADP + phosphate + 7,8-dihydrofolate
-
 ?
6.3.2.12 ATP + 7,8-dihydropteroate + L-Glu
-
 Mycobacterium avium ADP + phosphate + 7,8-dihydrofolate
-
 ?