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Literature summary extracted from

  • Hammer, L.; Levin-Salomon, V.; Yaeli-Slonim, N.; Weiss, M.; Dekel-Bird, N.P.; Olender, T.; Porat, Z.; Winograd-Katz, S.; Savidor, A.; Levin, Y.; Bialik, S.; Geiger, B.; Kimchi, A.
    A new function for the serine protease HtrA2 in controlling radiation-induced senescence in cancer cells (2022), Mol. Oncol., 16, 1365-1383.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 cytosol
-
 Homo sapiens 5829
-
3.4.21.108 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.108 vimentin + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 HCT-116 cell
-
 Homo sapiens
-
3.4.21.108 NCI-H460 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 vimentin + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.108 ? x * 36000, active enzyme, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 high-temperature requirement A2
-
 Homo sapiens
3.4.21.108 HtrA2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.108 metabolism the enzyme cleaves vimentin and affects vimentin assembly and polymerization following irradiation Homo sapiens
3.4.21.108 physiological function the enzyme is involved in the cytoskeletal reorganization that accompanies radiation-induced senescence and the continuous maintenance of proliferation arrest Homo sapiens