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Literature summary extracted from

  • Kummari, R.; Dutta, S.; Patil, S.; Mudrale, S.P.; Bose, K.
    Elucidating the role of GRIM-19 as a substrate and allosteric activator of pro-apoptotic serine protease HtrA2 (2021), Biochem. J., 478, 1241-1259.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.108 GRIM-19 significant allosteric activator of the enzyme Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.108 GRIM-19 + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 beta-casein + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.108 GRIM-19 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.108 GRIM-19 + H2O gene associated with retinoic and interferon-induced mortality 19, also known as NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 (NDUFA13). The cleavage sites are found between 19I-20D, 40I-41G, 49S-50I, 68R-69I, K97-100D and 108E-109S residues Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.108 ? x * 55000, full-length enzyme, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 high-temperature requirement A2
-
 Homo sapiens
3.4.21.108 HtrA2
-
 Homo sapiens