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Literature summary extracted from

  • Chaganti, L.K.; Dutta, S.; Kuppili, R.R.; Mandal, M.; Bose, K.
    Structural modeling and role of HAX-1 as a positive allosteric modulator of human serine protease HtrA2 (2019), Biochem. J., 476, 2965-2980.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.108 HAX-1 hematopoietic cell-specific protein 1-associated protein X-1, allosteric activator of the enzyme Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108 expressed in Escherichia coli BL21 (DE3) pLysS cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 cytoplasm
-
 Homo sapiens 5737
-
3.4.21.108 mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.108 HAX-1 + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens O43464
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.108 Ni-IDA affinity column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 beta-casein + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.108 HAX-1 + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.108 trimer 3 * 36000, mature enzyme, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 high-temperature requirement A2
-
 Homo sapiens
3.4.21.108 HtrA2
-
 Homo sapiens