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Literature summary extracted from
- pH induced conformational alteration in human peroxiredoxin 6 might be responsible for its resistance against lysosomal pH or high temperature (2021), Sci. Rep., 11, 9657 .
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.11.1.27 | expressed in Escherichia coli M15[pREP4] cells | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.11.1.27 | cytosol | the enzyme localized in cytosol shows glutathione peroxidase activity | Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.27 | 2 glutathione + H2O2 | Homo sapiens | - |
glutathione disulfide + 2 H2O | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.11.1.27 | Homo sapiens | P30041 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.11.1.27 | Ni-NTA agarose column chromatography | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.27 | 2 glutathione + H2O2 | - |
Homo sapiens | glutathione disulfide + 2 H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.11.1.27 | glutathione peroxidase | - |
Homo sapiens |
| 1.11.1.27 | peroxiredoxin 6 | bifunctional enzyme with glutathione peroxidase and calcium-independent phospholipase A2 activities | Homo sapiens |
| 1.11.1.27 | Prdx6 | - |
Homo sapiens |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.11.1.27 | 7 | - |
- |
Homo sapiens |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.11.1.27 | 6 | 10 | about 40% activity at pH 6.0, 100% activity at pH 7.0, about 90% activity at pH 8.0, about 70% activity at pH 9.0, about 60% activity at pH 10.0 | Homo sapiens |
pH Stability
| EC Number | pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.11.1.27 | 4 | 7 | the enzyme is thermodynamically more stable at pH 4.0 than at pH 7.0. Enzyme at pH 4.0 is resistant to thermal denaturation | Homo sapiens |
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Release 2023.1 (January 2023)
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