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Literature summary extracted from

  • Jonus, H.C.; Hanberry, B.S.; Khatu, S.; Kim, J.; Luesch, H.; Dang, L.H.; Bartlett, M.G.; Zastre, J.A.
    The adaptive regulation of thiamine pyrophosphokinase-1 facilitates malignant growth during supplemental thiamine conditions (2018), Oncotarget, 9, 35422-35438.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.6.2 medicine TPK1 is post-transcriptionally upregulated in cancer cells following hypoxic exposure. TPK1 expression is also adaptively upregulated following alterations of redox status by chemotherapeutic and antioxidant treatments. Despite upregulation by hypoxia, intracellular TPP levels are reduced. This loss was reversed by treatment with cell-permeable antioxidants and corresponds with reduced ROS production and enhanced cellular proliferation during supplemental thiamine conditions. siRNA-mediated knockdown of TPK1 directly enhances basal ROS levels and reduces tumor cell proliferation Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.6.2 Homo sapiens Q9H3S4
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-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.6.2 Caco-2 cell
-
 Homo sapiens
-
2.7.6.2 HCT-116 cell
-
 Homo sapiens
-
2.7.6.2 HuTu-80 cell
-
 Homo sapiens
-
2.7.6.2 LN-18 cell
-
 Homo sapiens
-
2.7.6.2 MCF-7 cell
-
 Homo sapiens
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2.7.6.2 MDA-MB-231 cell
-
 Homo sapiens
-
2.7.6.2 U-87MG cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
2.7.6.2 Tpk1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.6.2 physiological function TPK1 is post-transcriptionally upregulated in cancer cells following hypoxic exposure. TPK1 expression is also adaptively upregulated following alterations of redox status by chemotherapeutic and antioxidant treatments. Despite upregulation by hypoxia, intracellular TPP levels are reduced. This loss was reversed by treatment with cell-permeable antioxidants and corresponds with reduced ROS production and enhanced cellular proliferation during supplemental thiamine conditions. siRNA-mediated knockdown of TPK1 directly enhances basal ROS levels and reduces tumor cell proliferation Homo sapiens