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Literature summary extracted from

  • Gao, W.; Li, N.; Li, Z.; Xu, J.; Su, C.
    Ketohexokinase is involved in fructose utilization and promotes tumor progression in glioma (2018), Biochem. Biophys. Res. Commun., 503, 1298-1306 .
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.3 Homo sapiens P50053
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.3 brain expressed at significantly higher level in glioma tissues than in non-tumor brain Homo sapiens
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2.7.1.3 glioma cell expressed at significantly higher level in glioma tissues than in non-tumor brain Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.3 ATP + D-fructose
-
 Homo sapiens ADP + D-fructose 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.3 KHK
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.3 malfunction functionally, knockdown of ketohexokinase can significantly inhibit cell proliferation and migration of glioma cells in fructose medium Homo sapiens
2.7.1.3 metabolism key enzyme involved in fructose catabolism Homo sapiens
2.7.1.3 metabolism ketohexokinase overexpression is significantly correlated with tumor malignancy and poor survival of glioma patients Homo sapiens