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Literature summary extracted from
- Peroxiredoxin 6 in the repair of peroxidized cell membranes and cell signaling (2017), Arch. Biochem. Biophys., 617, 68-83 .
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.11.1.27 | Mus musculus | O08709 | - |
- |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.11.1.27 | peroxiredoxin 6 | - |
Mus musculus |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 1.11.1.27 | malfunction | Prdx6 null mice show increased lung or liver injury with exposure to hyperoxia, lipopolysaccharide (LPS), or paraquat. Prdx6 null mice as compared to wild type demonstrate increased age-related oxidative damage to their sperm chromatin | Mus musculus |
| 1.11.1.27 | physiological function | cells over-expressing Prdx6 show an increase in survival compared to control when oxidatively challenged with hydroperoxides, paraquat, UVB radiation, or OH generated by Cu2+/ascorbate. Prx6 over-expression through adenoviral-mediated intratracheal delivery of a Prdx6 expression vector or in transgenic mice protected lungs from hyperoxic injury. Prdx6 has an important role in the repair of peroxidized cell membranes, at least in lungs, and that both its PHGPx and PLA2 activities play important roles | Mus musculus |
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Release 2023.1 (January 2023)
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