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Literature summary extracted from
- Peptide selectivity between the PDZ domains of human pregnancy-related serine proteases (HtrA1, HtrA2, HtrA3, and HtrA4) can be reshaped by different halogen probes (2018), J. Mol. Recognit., 31, e2698 .
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.107 | DSRIWWV | native peptide ligand, binds to the domain with a moderately high affinity (Kd 1.9 microM). the peptide selectivity is changed by 1.4fold, 3.8fold, 7.0fold, and 2.1fold upon fluorination, chlorination, bromination, and iodization of the Trp-1 indole, respectively | Homo sapiens |  |
| 3.4.21.107 | FGRWV | peptide ligand | Homo sapiens | |
| 3.4.21.107 | WTMFWV | peptide ligand | Homo sapiens | |
| 3.4.21.108 | DSRIWWV | - |
Homo sapiens | |
| 3.4.21.108 | FGRWV | - |
Homo sapiens | |
| 3.4.21.108 | additional information | halogen substitutions at peptide inhibitor's Trp1 residue are most effective in improving peptide selectivity | Homo sapiens | |
| 3.4.21.108 | WTMFWV | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.107 | Homo sapiens | Q92743 | - |
- |
| 3.4.21.108 | Homo sapiens | O43464 | - |
- |
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