BRENDA - Enzyme Database

Biosynthesis and regulation of sulfomenaquinone, a metabolite associated with virulence in Mycobacterium tuberculosis

Sogi, K.M.; Holsclaw, C.M.; Fragiadakis, G.K.; Nomura, D.K.; Leary, J.A.; Bertozzi, C.R.; ACS Infect. Dis. 2, 800-806 (2016)

Data extracted from this reference:

Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
1.14.15.27
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
Mycobacterium tuberculosis
-
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
1.14.15.27
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
Mycobacterium tuberculosis H37Rv
-
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
Organism
EC Number
Organism
UniProt
Commentary
Textmining
1.14.15.27
Mycobacterium tuberculosis
P9WPN7
-
-
1.14.15.27
Mycobacterium tuberculosis H37Rv
P9WPN7
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
1.14.15.27
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
-
743926
Mycobacterium tuberculosis
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
1.14.15.27
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
-
743926
Mycobacterium tuberculosis H37Rv
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
Synonyms
EC Number
Synonyms
Commentary
Organism
1.14.15.27
cyp128
-
Mycobacterium tuberculosis
1.14.15.27
Rv2268c
-
Mycobacterium tuberculosis
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
1.14.15.27
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
Mycobacterium tuberculosis
-
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
1.14.15.27
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
Mycobacterium tuberculosis H37Rv
-
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
1.14.15.27
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
-
743926
Mycobacterium tuberculosis
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
1.14.15.27
beta-dihydromenaquinone-9 + 2 reduced ferredoxin [iron-sulfur] cluster + O2
-
743926
Mycobacterium tuberculosis H37Rv
omega-hydroxy-beta-dihydromenaquinone-9 + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
-
-
?
General Information
EC Number
General Information
Commentary
Organism
1.14.15.27
physiological function
Cyp128 and sulfotransferase Stf 3 are sufficient for the biosynthesis of sulfomenaquinone from menaquinone in recombinant Mycobacterium smegmatis. In a mouse model of infection the loss of Cyp128 exhibits a hypervirulent phenotype similar to that in previous studies of the Stf 3 mutant
Mycobacterium tuberculosis
General Information (protein specific)
EC Number
General Information
Commentary
Organism
1.14.15.27
physiological function
Cyp128 and sulfotransferase Stf 3 are sufficient for the biosynthesis of sulfomenaquinone from menaquinone in recombinant Mycobacterium smegmatis. In a mouse model of infection the loss of Cyp128 exhibits a hypervirulent phenotype similar to that in previous studies of the Stf 3 mutant
Mycobacterium tuberculosis