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Literature summary extracted from

  • Hansson, M.; Hederstedt, L.
    Cloning and characterization of the Bacillus subtilis hemEHY gene cluster, which encodes protoheme IX biosynthetic enzymes (1992), J. Bacteriol., 174, 8081-8093.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.99.1.9 expression in Escherichia coli Bacillus subtilis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.99.1.9 soluble
-
 Bacillus subtilis
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
4.99.1.9 35348
-
-
 Bacillus subtilis
4.99.1.9 40500
-
-
 Bacillus subtilis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.3.15 coproporphyrinogen III + O2 Bacillus subtilis
-
 coproporphyrin III + H2O
-
 ?
1.3.3.15 coproporphyrinogen III + O2 Bacillus subtilis 3G18
-
 coproporphyrin III + H2O
-
 ?
1.3.3.15 protoporphyrinogen IX + O2 Bacillus subtilis
-
 protoporphyrin IX + H2O
-
 ?
1.3.3.15 protoporphyrinogen IX + O2 Bacillus subtilis 3G18
-
 protoporphyrin IX + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.3.3.15 Bacillus subtilis
-
-
-
1.3.3.15 Bacillus subtilis 3G18
-
-
-
4.99.1.9 Bacillus subtilis P32396
-
-
4.99.1.9 Bacillus subtilis 168 P32396
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.3.15 coproporphyrinogen III + O2
-
 Bacillus subtilis coproporphyrin III + H2O
-
 ?
1.3.3.15 coproporphyrinogen III + O2
-
 Bacillus subtilis 3G18 coproporphyrin III + H2O
-
 ?
1.3.3.15 protoporphyrinogen IX + O2
-
 Bacillus subtilis protoporphyrin IX + H2O
-
 ?
1.3.3.15 protoporphyrinogen IX + O2
-
 Bacillus subtilis 3G18 protoporphyrin IX + H2O
-
 ?
4.99.1.9 protoporphyrin + Fe2+ i.e. reaction of EC 4.99.1.1 Bacillus subtilis protoheme + 2 H+
-
 ?
4.99.1.9 protoporphyrin + Fe2+ i.e. reaction of EC 4.99.1.1 Bacillus subtilis 168 protoheme + 2 H+
-
 ?
4.99.1.9 protoporphyrin IX + Zn2+
-
 Bacillus subtilis Zn protoporphyrin IX
-
 ?
4.99.1.9 protoporphyrin IX + Zn2+
-
 Bacillus subtilis 168 Zn protoporphyrin IX
-
 ?

Subunits

EC Number Subunits Comment Organism
4.99.1.9 ? x * 40500, SDS-PAGE, x * 35348, calculated Bacillus subtilis

Synonyms

EC Number Synonyms Comment Organism
1.3.3.15 hemY
-
 Bacillus subtilis
4.99.1.9 hemH
-
 Bacillus subtilis

General Information

EC Number General Information Comment Organism
1.3.3.15 metabolism the enzyme is required for a late step in protoheme IX synthesis Bacillus subtilis
4.99.1.9 physiological function a hemH mutant primarily accumulates protoporphyrin IX Bacillus subtilis