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Literature summary extracted from

  • Winkler, J.; Rand, M.L.; Schmugge, M.; Speer, O.
    Omi/HtrA2 and XIAP are components of platelet apoptosis signalling (2013), Thromb. Haemost., 109, 532-539.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 cytosol Omi/HtrA2 and Smac/Diablo are released from mitochondria into the platelet cytosol together with cytochrome c after induction of apoptosis by theCa2+ ionophore A23187 or the BH3 mimetic ABT-737, and to a lesser extent, after platelet stimulation with collagen and thrombin Homo sapiens 5829
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3.4.21.108 mitochondrion Omi/HtrA2 and Smac/Diablo are released from mitochondria into the platelet cytosol together with cytochrome c after induction of apoptosis by theCa2+ ionophore A23187 or the BH3 mimetic ABT-737, and to a lesser extent, after platelet stimulation with collagen and thrombin Homo sapiens 5739
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Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens O43464
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 blood platelet platelets contain the pro-apoptotic proteins Omi/HtrA2 and Smac/Diablo, as well as their target, the X-linked inhibitor of apoptosis XIAP Homo sapiens
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General Information

EC Number General Information Comment Organism
3.4.21.108 physiological function platelets contain the pro-apoptotic proteins Omi/HtrA2 and Smac/Diablo, as well as their target the X-linked inhibitor of apoptosis XIAP. Omi/HtrA2 and Smac/Diablo are released from mitochondria into the platelet cytosol together with cytochrome c after induction of apoptosis by theCa2+ ionophore A23187 or the BH3 mimetic ABT-737, and to a lesser extent, after platelet stimulation with collagen and thrombin Homo sapiens