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Literature summary extracted from

  • Chien, J.
    WT1 as a substrate of HtrA2: A potential pathway for therapeutic targeting by HtrA proteases (2010), Future Oncol., 6, 1233-1235.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.108 medicine HtrA2-mediated proteolysis of WT1 may directly contribute to the effect of cytotoxic drugs warrants Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 nucleus
-
 Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.108 Wilms' tumor suppressor protein WT1 + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 Wilms' tumor suppressor protein WT1 + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 high temperature requirement A2 protease
-
 Homo sapiens
3.4.21.108 HtrA2
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.21.108 physiological function HtrA2 acts as an apoptotic factor which targets inhibitors of apoptosis during apoptosis, and thereby enhances caspase activation and caspase-mediated cell death Homo sapiens