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Literature summary extracted from

  • Hata, S.; Abe, M.; Suzuki, H.; Kitamura, F.; Toyama-Sorimachi, N.; Abe, K.; Sakimura, K.; Sorimachi, H.
    Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense (2010), PLoS Genet., 6, e1001040.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.B28 additional information generation of Capn8-/- mice, that are fertile and whose gastric mucosae appears normal. However, the mutant mice are susceptible to gastric mucosal injury induced by ethanol administration, and the Capn8-/- stomach shows significant decreases in both calpains 9 and 8, and the same was true for Capn9-/-. Effects of calpain 8 deficiency on mucous granule formation and secretion, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.B28 cytosol
-
 Mus musculus 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.22.B28 Ca2+ dependent on Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.22.B28 additional information Mus musculus calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, in which both molecules are essential for activity, and that is involved in gastric mucosal defense. Calpains 8 and 9 are regulated differently from each other and from conventional calpains and, thus, have potentially important, specific functions in the gastrointestinal tract. Calpains 8 and 9 are molecular chaperones for each other, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.B28 Mus musculus Q91VA3
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.B28 mucosa gastric Mus musculus
-
3.4.22.B28 stomach calpain 8/nCL-2 is predominantly expressed in the gastrointestinal tract and is restricted to the gastric surface mucus cells in the stomach Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.B28 additional information calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, in which both molecules are essential for activity, and that is involved in gastric mucosal defense. Calpains 8 and 9 are regulated differently from each other and from conventional calpains and, thus, have potentially important, specific functions in the gastrointestinal tract. Calpains 8 and 9 are molecular chaperones for each other, overview Mus musculus ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.22.B28 additional information enzyme domain structure with prodomain, protease domain, C2-like domain, and 5EF-hand domain Mus musculus

Synonyms

EC Number Synonyms Comment Organism
3.4.22.B28 calpain 8/nCL-2
-
 Mus musculus
3.4.22.B28 additional information calpains constitute a superfamily of Ca2+-dependent cysteine proteases Mus musculus

General Information

EC Number General Information Comment Organism
3.4.22.B28 physiological function calpain 8 is involved in vesicle trafficking between endoplasmic reticulum and Golgi. Calpain 8/nCL-2 is also involved in the mucosal defense against stress-induced gastropathies Mus musculus