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Literature summary extracted from
- Glycogen synthase kinase-3 and Omi/HtrA2 induce annexin A2 cleavage followed by cell cycle inhibition and apoptosis (2009), Mol. Biol. Cell, 20, 4153-4161.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.108 | ucf-101 | treatment of lung epithelial adenocarcinoma cell A549 decreases the cleavage of annexin A2 under both serum withdrawal and cisplatin treatment | Homo sapiens |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.108 | cytosol | Omi/HtrA2 relocates from mitochondria to the cytosol in lung adenocarcinoma cell line A549 under serum withdrawal | Homo sapiens | 5829 | - |
| 3.4.21.108 | mitochondrion | immunostaining and confocal microscopy shows that Omi/HtrA2 is located primarily in the mitochondria of lung adenocarcinoma cell line A549 | Homo sapiens | 5739 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.108 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.108 | lung adenocarcinoma cell line | human lung epithelial adenocarcinoma cell A549 | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.108 | X-linked inhibitor of apoptosis protein + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.108 | Omi/HtrA2 | - |
Homo sapiens |
Expression
| EC Number | Organism | Comment | Expression |
|---|---|---|---|
| 3.4.21.108 | Homo sapiens | Omi/HtrA2 siRNA decreases the cleavage of annexin A2 lung epithelial adenocarcinoma cell A549 under both serum withdrawal and cisplatin treatment | down |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 3.4.21.108 | physiological function | Omi/HtrA2 is released from mitochondria to the cytosol and is required for annexin A2 cleavage under apoptotic stimuli | Homo sapiens |
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