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Literature summary extracted from

  • McCormick, A.L.; Roback, L.; Mocarski, E.S.
    HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA) (2008), PLoS Pathog., 4, e1000063.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.108 additional information HtrA2/Omi levels rise dramatically within mitochondria at late times during infection with cytomegalovirus Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108 into pDNA3.1+ Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.108 S306A catalytic site mutant Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.108 5-[5-(2-nitrophenyl)furfuryliodine]1,3-diphenyl-2-thiobarbituric acid UCF-101 Homo sapiens
3.4.21.108 TLCK
-
 Homo sapiens
3.4.21.108 viral mitochondrial inhibitor of apoptosis vMIA Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.108 36000
-
 HtrA2, determined by SDS-PAGE and Western Blot analysis Homo sapiens
3.4.21.108 49000
-
 pro-HtrA2, determined by SDS-PAGE and Western Blot analysis Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens O43464
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 fibroblast
-
 Homo sapiens
-
3.4.21.108 HeLa cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 HtrA2/Omi
-
 Homo sapiens
3.4.21.108 serine protease
-
 Homo sapiens