Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Yun, J.; Cao, J.H.; Dodson, M.W.; Clark, I.E.; Kapahi, P.; Chowdhury, R.B.; Guo, M.
    Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the PINK1/PARKIN pathway in vivo (2008), J. Neurosci., 28, 14500-14510.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.21.108 medicine mutations in the OMI/HTRA2 gene are linked to Parkinsons disease Drosophila melanogaster

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108 into the vectors pUASt and pTMR Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.108 G363S Drosophila Omi mutant analogous to human Omi/HtrA2 mutation G399S Drosophila melanogaster
3.4.21.108 S236C Drosophila Omi mutant analogous to human Omi/HtrA2 mutation S276C Drosophila melanogaster
3.4.21.108 S266A Drosophila Omi mutant analogous to human Omi/HtrA2 mutation S306A Drosophila melanogaster
3.4.21.108 S364A Drosophila Omi mutant analogous to human Omi/HtrA2 mutation S400A Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 cytosol released into the cytosol upon apoptotic stimuli Drosophila melanogaster 5829
-
3.4.21.108 mitochondrial intermembrane space
-
 Drosophila melanogaster 5758
-
3.4.21.108 mitochondrion
-
 Drosophila melanogaster 5739
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Drosophila melanogaster Q9VFJ3
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.108 phosphoprotein
-
 Drosophila melanogaster

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 eye
-
 Drosophila melanogaster
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 Omi/HtrA2
-
 Drosophila melanogaster
3.4.21.108 serine protease
-
 Drosophila melanogaster