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Literature summary extracted from

  • Han, C.; Nam, M.K.; Park, H.J.; Seong, Y.M.; Kang, S.; Rhim, H.
    Tunicamycin-induced ER stress upregulates the expression of mitochondrial HtrA2 and promotes apoptosis through the cytosolic release of HtrA2 (2008), J. Microbiol. Biotechnol., 18, 1197-1202.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.108 additional information HtrA2 protein level is gradually and significantly increased by up to 10fold in the mitochondria under tunicamycin-induced ER stress Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108 yes into the ecdysone-inducible eukaryotic expression vector pIND Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 cytosol released into the cytosol upon apoptotic stimuli Homo sapiens 5829
-
3.4.21.108 mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.108 37400
-
 mature HtrA2, determined by SDS-PAGE and Western blot analysis Homo sapiens
3.4.21.108 49500
-
 HtrA2 precursor, determined by SDS-PAGE and Western blot analysis Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.108 mitochondrial fractions of HEK-293T cells are prepared Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 HEK-293 cell
-
 Homo sapiens
-
3.4.21.108 HEK-293T cell
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 HtrA2
-
 Homo sapiens