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Literature summary extracted from

  • Bhuiyan, M.S.; Fukunaga, K.
    Mitochondrial serine protease HtrA2/Omi as a potential therapeutic target (2009), Curr. Drug Targets, 10, 372-383.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.108 medicine HtrA2 is linked to cancer and neurodegeneration, like Alzheimers disease, Parkinsons disease, Huntingtons disease, and brain, kidney and myocardial ischemia, reperfusion Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.108 5-[5-(2-nitrophenyl)furfuryliodine]1,3-diphenyl-2-thiobarbituric acid UCF-101 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 cytosol released into the cytosol upon apoptotic stimuli Homo sapiens 5829
-
3.4.21.108 mitochondrial intermembrane space
-
 Homo sapiens 5758
-
3.4.21.108 mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.108 36000
-
 cleaved, activated form Homo sapiens
3.4.21.108 50000
-
 precursor HtrA2 Homo sapiens
3.4.21.108 110000
-
 trimer, determined by gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 alpha-casein + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.108 amyloid precursor protein + H2O APP Homo sapiens ?
-
 ?
3.4.21.108 Apollon + H2O BRUCE-apollon Homo sapiens ?
-
 ?
3.4.21.108 beta-casein + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.108 Fas-Fas L + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.108 FLIP + H2O Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein Homo sapiens ?
-
 ?
3.4.21.108 glycoprotein alpha1 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.108 HS1-associated protein X1 + H2O HAX-1 Homo sapiens ?
-
 ?
3.4.21.108 hyaluronidase + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.108 inhibitor of apoptosis + H2O IAP Homo sapiens ?
-
 ?
3.4.21.108 PED-PEA 15 + H2O death effector domain-containing protein Homo sapiens ?
-
 ?
3.4.21.108 WARTS kinase + H2O WARTS, WTS, large tumor-suppressor 1 mitotic kinase Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.108 homotrimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 high temperature requirement A2
-
 Homo sapiens
3.4.21.108 serine protease HtrA2/Omi
-
 Homo sapiens