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Literature summary extracted from

  • Tain, L.S.; Chowdhury, R.B.; Tao, R.N.; Plun-Favreau, H.; Moisoi, N.; Martins, L.M.; Downward, J.; Whitworth, A.J.; Tapon, N.
    Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin (2009), Cell Death Differ., 16, 1118-1125.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.21.108 medicine HtrA2 is linked to Parkinsons disease Drosophila melanogaster

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108 into the vectors pCaSpeR-HS and pUASp Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.108 HtrA2DELTA1 deletion mutant, the P-element G4907 is excised to produce a deletion of 1037 bp Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 mitochondrion
-
 Drosophila melanogaster 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.108 35000
-
 cleaved form, mitochondrial import Drosophila melanogaster
3.4.21.108 37000
-
 cleaved form, mitochondrial import Drosophila melanogaster
3.4.21.108 46000
-
 full-length protein Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Drosophila melanogaster Q9VFJ3
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.108 phosphoprotein
-
 Drosophila melanogaster

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 brain
-
 Drosophila melanogaster
-
3.4.21.108 neuron
-
 Drosophila melanogaster
-
3.4.21.108 testis
-
 Drosophila melanogaster
-
3.4.21.108 thorax
-
 Drosophila melanogaster
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 high temperature requirement A2
-
 Drosophila melanogaster
3.4.21.108 HtrA2
-
 Drosophila melanogaster
3.4.21.108 HtrA2/Omi
-
 Drosophila melanogaster