Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Marabese, M.; Mazzoletti, M.; Vikhanskaya, F.; Broggini, M.
    HtrA2 enhances the apoptotic functions of p73 on bax (2008), Cell Death Differ., 15, 849-858.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.108 medicine the relation between p73 and HtrA2 may help to understand the behavior of the p73 protein in the responses of cancer cells to chemotherapy Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108 into the vector pCMV/SPORT Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.108 S306A proteolytically inactive mutant Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.108 HtrA2 siRNA
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 mitochondrion healthy cell Homo sapiens 5739
-
3.4.21.108 nucleus following apoptotic stimuli, HtrA2 accumulates in the nucleus Homo sapiens 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.108 additional information Homo sapiens HtrA2 cleaves p73alpha in the C-terminal portion ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 HCT-116 cell
-
 Homo sapiens
-
3.4.21.108 NCI-H1299 cell human non-small-cell lung carcinoma cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 additional information HtrA2 cleaves p73alpha in the C-terminal portion Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 HtrA2
-
 Homo sapiens
3.4.21.108 serine protease
-
 Homo sapiens