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Literature summary extracted from

  • Bhuiyan, M.S.; Fukunaga, K.
    Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury (2008), Cardiovasc. ther., 26, 224-232.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.108 medicine therapeutic interventions that inhibit HtrA2 expression, translocation, or protease activity may provide attractive therapeutics in the treatment of cardiovascular diseases Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.108 5-[5-(2-nitrophenyl)furfuryliodine]1,3-diphenyl-2-thiobarbituric acid UCF-101 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 cytosol translocation from mitochondria to cytosol Homo sapiens 5829
-
3.4.21.108 mitochondrion translocation from mitochondria to cytosol Homo sapiens 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.108 36000
-
 predicted Homo sapiens
3.4.21.108 110000
-
 determined by gel filtration Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 cardiac myocyte
-
 Homo sapiens
-
3.4.21.108 heart
-
 Homo sapiens
-

Subunits

EC Number Subunits Comment Organism
3.4.21.108 homotrimer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 high temperature requirement A2 serine protease
-
 Homo sapiens
3.4.21.108 HtrA2
-
 Homo sapiens
3.4.21.108 HtrA2 serine protease
-
 Homo sapiens
3.4.21.108 HtrA2/Omi
-
 Homo sapiens