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Literature summary extracted from

  • Plun-Favreau, H.; Gandhi, S.; Wood-Kaczmar, A.; Deas, E.; Yao, Z.; Wood, N.W.
    What have PINK1 and HtrA2 genes told us about the role of mitochondria in Parkinsons disease? (2008), Ann. N. Y. Acad. Sci., 1147, 30-36.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.108 additional information phosphorylation Homo sapiens

Application

EC Number Application Comment Organism
3.4.21.108 medicine the identification of the role of HtrA2 in neurodegeneration will lead to an improved understanding of the pathogenesis of Parkinsons disease Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.108 A141S polymorphism associated with Parkinsons disease Homo sapiens
3.4.21.108 G399S heterozygous mutation identified in Parkinsons disease patients Homo sapiens
3.4.21.108 S142D recombinant HtrA2 mutant, produced to determine whether HtrA2 phosphorylation affects its proteolytic activity Homo sapiens
3.4.21.108 S400D recombinant HtrA2 mutant, produced to determine whether HtrA2 phosphorylation affects its proteolytic activity Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.108 35000
-
 determined by SDS-PAGE and Western Blot analysis Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.21.108 phosphoprotein Ser142 and Ser400 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 brain
-
 Homo sapiens
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 HtrA2
-
 Homo sapiens