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Literature summary extracted from

  • Ma, X.; Kalakonda, S.; Srinivasula, S.M.; Reddy, S.P.; Platanias, L.C.; Kalvakolanu, D.V.
    GRIM-19 associates with the serine protease HtrA2 for promoting cell death (2007), Oncogene, 26, 4842-4849.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.108 GRIM-19 direct enhancement of HtrA2 activity in vitro. HtrA2-driven destruction of the antiapoptotic X-linked inhibitor of apoptosis protein is augmented Homo sapiens
3.4.21.108 IFN/all-trans retinoic acid enhances interaction of GRIM-19 with HtrA2. Causes a concurrent release of HtrA2 and GRIM-19 from mitochondria Homo sapiens

Application

EC Number Application Comment Organism
3.4.21.108 medicine critical role of HtrA2 in a cytokine-induced cell death response. Inhibition by a viral protein Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108 coexpression of Flag-tagged and Ndelta133 HtrA2 proteins and a myc-epitope-tagged GRIM-19 protein in MCF-7 cells. MCF-7 cells transfected with expression vectors coding for GFP-HtrA2 and GFP-HtrA2-S306A and GRIM-19 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.108 S306A catalytically inactive Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.108 antisense HtrA2 significantly inhibits IFN/all-trans retinoic acid-induced degradation of X-linked inhibitor of apoptosis protein Homo sapiens
3.4.21.108 vIRF1 human herpes virus-8 (HHV-8)-coded oncoprotein, disrupts interactions of GRIM-19 with HtrA2 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 X-linked inhibitor of apoptosis protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 serine protease HtrA2
-
 Homo sapiens