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Literature summary extracted from

  • Liu, M.L.; Liu, M.J.; Kim, J.M.; Kim, H.J.; Kim, J.H.; Hong, S.T.
    HtrA2 interacts with A beta peptide but does not directly alter its production or degradation (2005), Mol. Cell, 20, 83-89.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.21.108 medicine involvement of HtrA2 in the etiology of Alzheimer's disease Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108 subcloned into pET28a and propageted in Escherichia coli DH5alpha, expressed in Escherichia coli BL21 (DE3) pLys, overexpression in K269 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 mitochondrion mainly localized Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.108 recombinant enzyme by ProBondTM resin Homo sapiens

Storage Stability

EC Number Storage Stability Organism
3.4.21.108 -80°C, phosphate buffered saline, pH 7.4, 20% glycerol Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 A beta 40 HtrA2/Omi binds preferentially to the short form of A beta peptides, the enzyme does not perform degradation by direct hydrolysis Homo sapiens ?
-
 ?
3.4.21.108 A beta 42 HtrA2/Omi binds poorly to A beta 42, the enzyme does not perform degradation by direct hydrolysis Homo sapiens ?
-
 ?
3.4.21.108 alpha-secretase peptide HtrA2/Omi does not perform degradation by direct hydrolysis Homo sapiens ?
-
 ?
3.4.21.108 beta-secretase peptide HtrA2/Omi does not perform degradation by direct hydrolysis Homo sapiens ?
-
 ?
3.4.21.108 casein + H2O strong hydrolytic activity Homo sapiens ?
-
 ?
3.4.21.108 gamma-secretase peptide HtrA2/Omi binds less strongly to gamma-secretase substrate peptide as compared to alpha-secretase substrate peptide and beta-secretase substrate peptide, the enzyme does not perform degradation by direct hydrolysis Homo sapiens ?
-
 ?
3.4.21.108 additional information does not bind the reversed control peptide A beta 41-1 and peptide H2-Opt Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 HtrA2/Omi
-
 Homo sapiens