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Literature summary extracted from

  • Trencia, A.; Fiory, F.; Maitan, M.A.; Vito, P.; Barbagallo, A.P.; Perfetti, A.; Miele, C.; Ungaro, P.; Oriente, F.; Cilenti, L.; Zervos, A.S.; Formisano, P.; Beguinot, F.
    Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15 (2004), J. Biol. Chem., 279, 46566-46572.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.108 additional information UV irradiation leads to an almost complete disappearance of mitochondrial Omi/HtrA2 and a parallel appearance of Omi/HtrA2 in the cytoplasm, induction of Omi/HtrA2 binding to ped/pea-15 Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108 overexpression in HeLa cells and HEK-293 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.108 ucf-101 inhibits degradation of endogenous ped/pea-15 by Omi/HtrA2 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 cytoplasm
-
 Homo sapiens 5737
-
3.4.21.108 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 HEK-293 cell
-
 Homo sapiens
-
3.4.21.108 HeLa cell
-
 Homo sapiens
-
3.4.21.108 kidney from embryos Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 ped/pea-15 HtrA2 is a specific interactor of the ped/pea-15 death effector domain and leads to its degradation Homo sapiens ?
-
 ?
3.4.21.108 X-linked inhibitor of apoptosis protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 Omi/HtrA2
-
 Homo sapiens
3.4.21.108 serine protease
-
 Homo sapiens