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Literature summary extracted from

  • Gupta, S.; Singh, R.; Datta, P.; Zhang, Z.; Orr, C.; Lu, Z.; Dubois, G.; Zervos, A.S.; Meisler, M.H.; Srinivasula, S.M.; Fernandes-Alnemri, T.; Alnemri, E.S.
    The C-terminal tail of presenelin regulates Omi/HtrA2 protease activity (2004), J. Biol. Chem., 279, 45844-45854.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.107 15 residue presenilin-1 peptide activation Escherichia coli
3.4.21.107 additional information no activation by 3 residue presenelin-1 peptide Escherichia coli
3.4.21.107 OMP C-terminal tripeptide YYF-COOH activation less efficient as compared to 15 residue presenilin-1 peptide Escherichia coli

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.107 cloned into pET28a Escherichia coli
3.4.21.108 expression in Escherichia coli and MEF cells from mnd2 mouse Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.108 L286V Alzheimer mutant presenilin-1 Homo sapiens
3.4.21.108 M146V Alzheimer mutant presenilin-1 Homo sapiens
3.4.21.108 S276C deletion of the PDZ domain of Omi/HtrA2 Homo sapiens
3.4.21.108 S306A catalytically inactive Omi/HtrA2 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 cytoplasm
-
 Homo sapiens 5737
-
3.4.21.108 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.107 Escherichia coli
-
-
-
3.4.21.108 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.108
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 HEK-293 cell
-
 Homo sapiens
-
3.4.21.108 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.107 beta-casein + H2O nonphysiological substrate of DegP Escherichia coli ?
-
 ?
3.4.21.107 additional information unable to cleave inhibitor of apoptosis protein Escherichia coli ?
-
 ?
3.4.21.107 RseA + H2O physiological substrate of DegP Escherichia coli ?
-
 ?
3.4.21.108 35S-beta-casein + H2O C-terminus of presenilin-1 interacts the PDZ domain of with Omi/HtrA2, increasing its activity Homo sapiens ?
-
 ?
3.4.21.108 c-inhibitor of apoptosis protein1 + H2O C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity Homo sapiens ?
-
 ?
3.4.21.108 c-inhibitor of apoptosis protein2 + H2O C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity Homo sapiens ?
-
 ?
3.4.21.108 X-linked inhibitor of apoptosis protein + H2O C-terminus of presenilin-1 interacts with the PDZ domain of Omi/HtrA2, increasing its activity Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.107 DegP
-
 Escherichia coli
3.4.21.108 Omi/HtrA2
-
 Homo sapiens
3.4.21.108 serine protease
-
 Homo sapiens