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Literature summary extracted from

  • Seong, Y.M.; Choi, J.Y.; Park, H.J.; Kim, K.J.; Ahn, S.G.; Seong, G.H.; Kim, I.K.; Kang, S.; Rhim, H.
    Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP (2004), J. Biol. Chem., 279, 37588-37596.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.108 staurosporine apoptotic stimulus to release 36-kDa protein fragment of HtrA2 and cytochrome c from the mitochondria to the cytosol Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108 expression as GST fusions in Escherichia coli BL21 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.108 S306A endoproteolytic activity abolished Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 cytosol
-
 Homo sapiens 5829
-
3.4.21.108 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Bos taurus
-
-
-
3.4.21.108 Homo sapiens
-
-
-
3.4.21.108 Mus musculus
-
-
-
3.4.21.108 Rattus norvegicus
-
-
-
3.4.21.108 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.108 by glutathione-Sepharose 4B beads Homo sapiens

Storage Stability

EC Number Storage Stability Organism
3.4.21.108 -70°C, Tris-HCl buffer, 20% glycerol, several months Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 beta-casein + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.108 X-linked inhibitor of apoptosis protein + H2O autocatalytically processing of HtrA2 to the 36-kDa protein fragment, which is required for the cytochrome c-dependent caspase activation, promoting apoptotic cell death Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 HtrA2/Omi
-
 Homo sapiens
3.4.21.108 HtrA2/Omi
-
 Mus musculus
3.4.21.108 HtrA2/Omi
-
 Rattus norvegicus
3.4.21.108 HtrA2/Omi
-
 Bos taurus
3.4.21.108 HtrA2/Omi
-
 Sus scrofa
3.4.21.108 serine protease
-
 Homo sapiens
3.4.21.108 serine protease
-
 Mus musculus
3.4.21.108 serine protease
-
 Rattus norvegicus
3.4.21.108 serine protease
-
 Bos taurus
3.4.21.108 serine protease
-
 Sus scrofa