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Literature summary extracted from

  • Nam, M.K.; Seong, Y.M.; Park, H.J.; Choi, J.Y.; Kang, S.; Rhim, H.
    The homotrimeric structure of HtrA2 is indispensable for executing its serine protease activity (2006), Exp. Mol. Med., 38, 26-43.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.108 L-phenylalanine essential for the formation of a homotrimer and for the HtrA2 serine protease activity Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108 expression of GST-HtrA2 delta 133 proteins in Escherichia coli BL21 from GST-HTRA2 delta 133 WT, S306 and F149D constructs Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.21.108 63000
-
 most of the purified GST-HtrA2 delta 133 proteins Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.108 rapid purification of GST-HtrA2 delta 133 proteins on glutathione-Sepharose 4B beads Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 kidney embryonic kindey 293 cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 (35S) Met-labeled proteolytically inactive S306 form of full length HtrA2 + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.108 beta-casein + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.108 X-linked inhibitor of apoptosis protein + H2O homotrimeric structure of enzyme is required for executing its activity Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.108 trimer homotrimer, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 HtrA2
-
 Homo sapiens
3.4.21.108 serine protease
-
 Homo sapiens