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Literature summary extracted from

  • Blink, E.; Maianski, N.A.; Alnemri, E.S.; Zervos, A.S.; Roos, D.; Kuijpers, T.W.
    Intramitochondrial serine protease activity of Omi/HtrA2 is required for caspase-independent cell death of human neutrophils (2004), Cell Death Differ., 11, 937-939.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.108 ucf-101 0.02 mM abrogates the death effect of the TNF-alpha + zVAD combination Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 cytoplasm HtrA2 relocates to the cytoplasm upon apoptosis Homo sapiens 5737
-
3.4.21.108 mitochondrion normally expression of HtrA2, enzyme does not leave the mitochondria upon the TNF-alpha + zVAD-induced cell death in neutrophils Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 neutrophil from the peripheral blood of healthy donors Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 X-linked inhibitor of apoptosis protein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 Omi/HtrA2
-
 Homo sapiens
3.4.21.108 serine protease
-
 Homo sapiens