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Literature summary extracted from

  • Suzuki, Y.; Takahashi-Niki, K.; Akagi, T.; Hashikawa, T.; Takahashi, R.
    Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways (2004), Cell Death Differ., 11, 208-216.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108 expression in Escherichia coli BL21 (DE3) pLysS Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 mitochondrion intermembrane space Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.108 by nickel affinity chromatography and HiTrap desalting Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 HeLa cell human cervical carcinoma Homo sapiens
-
3.4.21.108 kidney from human embryos Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
3.4.21.108 -80°C, HEPES-KOH buffer, pH 7.5 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 unidentified substrate + H2O its cleavage by Omi/HtrA2 leads to permeabilization of the mitochondria outer membrane and release of chytochrome c followed by enhanced caspase activation Homo sapiens ?
-
 ?
3.4.21.108 X-linked inhibitor of apoptosis protein + H2O Omi/HtrA2 cleaves as well as directly binds and inactivates X-linked inhibitor of apoptosis protein to promote caspase activation Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 Omi/HtrA2
-
 Homo sapiens
3.4.21.108 serine protease
-
 Homo sapiens