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Literature summary extracted from

  • Zhang, X.; Chang, Z
    Temperature dependent protease activity and structural properties of human HtrA2 protease (2004), Biochemistry (Moscow), 69, 687-692.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108 expression from pET-15b Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.21.107 additional information degP null mutant strain CLC198 Escherichia coli

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.107 Escherichia coli
-
-
-
3.4.21.108 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.108 on Ni-NTA agarose column Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 casein + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.107 DegP
-
 Escherichia coli
3.4.21.108 HtrA2
-
 Homo sapiens
3.4.21.108 HtrA2 protease
-
 Homo sapiens

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
3.4.21.107 44
-
 at 44 °C function of DegP in mutant strain CLC198 can be complemented by HtrA2 Escherichia coli
3.4.21.108 25 55 enzyme activity rapidly increases with temperature and it drastically decreases at and above 60°C, no significant change in secondary structure from 25-70 °C or in the oligomeric size between 25-55 °C, but significant change in tertiary level from 25-60 °C Homo sapiens