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Literature summary extracted from

  • Murwantoko, C.; Yano, M.; Ueta, Y.; Murasaki, A.; Kanda, H.; Oka, C.; Kawaichi, M.
    Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease (2004), Biochem. J., 381, 895-904.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108 expression in Escherichia coli BL21 (DE3) Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.108 with Ni-NTA-agarose column Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 HEK-293 cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.21.108 additional information
-
 peptide derived from type III collagen alpha1 C-propeptide does not activate nor significantly bind to HtrA2 as compared to HtrA1 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 reduced bovine serum albumin HtrA2-Opt peptides stimulate the delta N-HtrA1 protease activity more than 3fold Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 high temperature requirement A serine protease
-
 Homo sapiens
3.4.21.108 HtrA2/Omi
-
 Homo sapiens