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Literature summary extracted from

  • Cilenti, L.; Kyrizis, G.A.; Soundarapandian, M.M.; Stratico, V.; Yerkes, A.; Park, K.M.; Sheridan, A.M.; Alnemri, E.S.; Bonventre, J.V.; Zervos, A.S.
    Omi/HtrA2 protease mediates cisplatin-induced cell death in renal cells (2005), Am. J. Physiol. Renal Physiol., 288, F371-F379.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.108 cisplatin increase of Omi protein Homo sapiens
3.4.21.108 cisplatin increase of Omi protein Mus musculus

Application

EC Number Application Comment Organism
3.4.21.108 medicine way to limit renal injury by specifically inhibiting its proteolytic activity Homo sapiens
3.4.21.108 medicine way to limit renal injury by specifically inhibiting its proteolytic activity Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.108 ucf-101 blocks protease activity of Omi, protects renal cells from cisplatin-induced cell death, together with 0.05 mM cisplatin, 0.07 mM ucf-101 can block X-linked inhibitor of apoptosis protein degradation Homo sapiens
3.4.21.108 ucf-101 blocks protease activity of Omi, protects renal cells from cisplatin-induced cell death, mice treated with cisplatin and ucf-101 were more resistant to nephrotoxicy than animals treated with ciplatin alone Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.108 cytoplasm
-
 Homo sapiens 5737
-
3.4.21.108 cytoplasm
-
 Mus musculus 5737
-
3.4.21.108 mitochondrion
-
 Homo sapiens 5739
-
3.4.21.108 mitochondrion predominant presence of Omi Mus musculus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-
3.4.21.108 Mus musculus
-
 C57BL6
-
3.4.21.108 Mus musculus C57BL6
-
 C57BL6
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.108 HEK-293 cell
-
 Homo sapiens
-
3.4.21.108 kidney from human embryos Homo sapiens
-
3.4.21.108 kidney from the cortices Mus musculus
-
3.4.21.108 additional information proximal cells, HK-2 cells Homo sapiens
-
3.4.21.108 proximal tubule
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 X-linked inhibitor of apoptosis protein + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.108 X-linked inhibitor of apoptosis protein + H2O
-
 Mus musculus ?
-
 ?
3.4.21.108 X-linked inhibitor of apoptosis protein + H2O
-
 Mus musculus C57BL6 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 Omi/HtrA2 protease
-
 Homo sapiens
3.4.21.108 Omi/HtrA2 protease
-
 Mus musculus
3.4.21.108 serine protease
-
 Homo sapiens
3.4.21.108 serine protease
-
 Mus musculus