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Literature summary extracted from

  • Melnick, J.S.; Sprinz, K.I.; Reddick, J.J.; Kinsland, C.; Begley, T.P.
    An efficient enzymatic synthesis of thiamin pyrophosphate (2003), Bioorg. Med. Chem. Lett., 13, 4139-4141.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.4.16 construction of the thiamine monophosphate kinase (thiL) overexpression plasmid, overexpression from pCLK710 Escherichia coli
2.7.6.2 overexpression in Escherichia coli Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.4.16 ATP + thiamine phosphate Escherichia coli enzyme is involved in thiamin diphosphate biosynthesis ADP + thiamine diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.16 Escherichia coli
-
-
-
2.7.6.2 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.4.16 partial Escherichia coli
2.7.6.2
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.16 ATP + thiamine phosphate enzyme is involved in thiamin diphosphate biosynthesis Escherichia coli ADP + thiamine diphosphate
-
 ?
2.7.6.2 ATP + thiamine enzyme is involved in biosynthesis of thiamine diphosphate Saccharomyces cerevisiae AMP + thiamine diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.16 thiamin monophosphate kinase
-
 Escherichia coli
2.7.4.16 thiamin phosphate kinase
-
 Escherichia coli
2.7.6.2 thiamin pyrophosphokinase
-
 Saccharomyces cerevisiae