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Literature summary extracted from

  • Martins, L.M.; Turk, B.E.; Cowling, V.; Borg, A.; Jarrell, E.T.; Cantley, L.C.; Downward, J.
    Binding specificity and regulation of the serine protease and PDZ domains of HtrA2/Omi (2003), J. Biol. Chem., 278, 49417-49427.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.108 heat shock pre-incubation of Omi at 42°C for 30 min results in increased proteolytic activity Homo sapiens
3.4.21.108 X-linked inhibitor of apoptosis protein i.e. XIAP, binding of XIAP to the Reaper motif of the enzyme results in a marked increase in proteolytic activity Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.108 PDZ domain Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.108 additional information Homo sapiens role in apoptosis, amino-terminal IAP interaction motif displaces IAPs from caspases, leading to enhanced caspase activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.108 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.108
-
 Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.108 (7-methoxycoumarin-4-yl)acetyl-IRRVSYSF(Dnp)KK + H2O best substrate Homo sapiens ?
-
 ?
3.4.21.108 (7-methoxycoumarin-4-yl)acetyl-VTLCAVPS(Dnp)KK + H2O cleavage occurs between cysteine and alanine Homo sapiens ?
-
 ?
3.4.21.108 beta-casein + H2O main selectivity at position P1 is for non-polar aliphatic amino acids, in particular valine, isoleucine and methionine. At the P2 and P3 positions arginine is selected most strongly with a secondary selection for other hydrophilic residues Homo sapiens ?
-
 ?
3.4.21.108 additional information role in apoptosis, amino-terminal IAP interaction motif displaces IAPs from caspases, leading to enhanced caspase activity Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.108 HtrA2/Omi
-
 Homo sapiens