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Literature summary extracted from
- The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif (2002), J. Biol. Chem., 277, 439-444.
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 3.4.21.108 | additional information | truncated mutant lacking the putative mitochondrial localization motif in the first 33 amino acid residues shows distribution throughout the cell with no obvious concentration in the mitochondria | Homo sapiens |
| 3.4.21.108 | S306A | localization is similar to wild-type | Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.21.108 | mitochondrion | mitochondria also contain processed Omi which, following apoptotic insult, translocates to the cytosol | Homo sapiens | 5739 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.108 | 35000 | - |
mass spectroscopy experiments | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.108 | additional information | Homo sapiens | role in apoptosis, binds to XIAP-binding protein | ? | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.108 | Homo sapiens | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.21.108 | proteolytic modification | first 133 amino acids are removed by autoproteolysis | Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.108 | 293 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.108 | beta-casein + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.108 | additional information | role in apoptosis, binds to XIAP-binding protein | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.21.108 | HtrA2/Omi | - |
Homo sapiens |
| 3.4.21.108 | Omi | - |
Homo sapiens |
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